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目的分析新疆经典型卡波氏肉瘤相关危险因素。方法利用新疆8个地州市随访的经典型卡波氏肉瘤病例,按同性别、同民族、年龄相差≤5岁、同一个居住地区配对要求,1:4选取对照,开展病例对照研究,采用条件logistic回归进行统计分析。结果单因素分析显示:白细胞介素、血管内皮生长因子、β2微球蛋白(β2-MG)、新喋呤和8型疱疹病毒(HHV-8)等5个相关因素与经典型卡波氏肉瘤有关系。β2-MG和HHV-8两项危险因素进入了多因素条件logistic回归模型,其OR值分别为1.002(95%CI:1.000～1.003)、81.041(95%CI:1.790～3669.620)。结论β2-MG与经典型卡波氏肉瘤的发生呈正相关关系,HHV-8感染是经典型卡波氏肉瘤独立的危险因素。
Objective To analyze the related risk factors of Kaposi’s sarcoma in Xinjiang. Methods According to the classic cases of Kaposi’s sarcoma followed up in 8 prefectures and cities in Xinjiang, the case-control study was conducted according to the same gender, age, Conditional logistic regression was used for statistical analysis. Results Univariate analysis showed that five related factors, interleukin, vascular endothelial growth factor, β2 microglobulin (β2-MG), neopterin and herpes simplex virus type 8 (HHV-8), were associated with classical Kaposi’s sarcoma There are relationships. The two risk factors, β2-MG and HHV-8, entered the multivariate conditional logistic regression model with ORs of 1.002 (95% CI: 1.000-1.003) and 81.041 (95% CI: 1.790-3,669.620), respectively. Conclusion β2-MG is positively correlated with the occurrence of classical Kaposi’s sarcoma. HHV-8 infection is an independent risk factor for classical Kaposi’s sarcoma.