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目的观察涪陵地区食盐碘化后甲状腺功能亢进症(甲亢)病例就诊变化趋势和临床特点,分析影响因素。方法收集2000-2009年涪陵地区涪陵中心医院门诊甲亢病例资料;以T3(FT3)或T4(FT4)升高、TSH降低,结合病人甲亢临床表现诊断为甲亢;计算甲亢年发现率;用F检验分析甲状腺容积和肿大变化趋势,χ2检验分析甲亢年发现率变化。结果共发现甲亢病例1995例,年均病例发现率为17.78/10万,其中,2000-2003年发现率为14.55/10万,2004-2009年发现率为19.85/10万,后阶段显著高于前阶段(χ2=42.83,P<0.01)。患者甲状腺容积平均为46.15ml,肿大率为79.80%,甲状腺容积和肿大率均呈下降趋势(F=22.13、62.84,P<0.01)。30岁起,随着年龄的增长,甲状腺容积和甲状腺肿大率均呈下降趋势(F=31.02、117.50,P<0.01/0.05);病例女性多于男性(1∶2.5),发病主要年龄集中在20～50岁组(占92.94%)。结论涪陵区2000-2009年甲亢发现率呈上升趋势,甲亢患者甲状腺容积和甲状腺肿大率呈下降趋势,可能与全民食盐加碘有关。
Objective To observe the change trends and clinical features of hyperthyroidism (hyperthyroidism) cases after salt iodization in Fuling area and to analyze the influencing factors. Methods The data of outpatient hyperthyroidism in Fuling Central Hospital from 2000 to 2009 were collected. Thyroidism was diagnosed as Hyperthyroidism with T3 (FT3) or T4 (FT4) elevation and TSH reduction. The incidence of hyperthyroidism was calculated. F-test Analysis of thyroid volume and swelling trends, χ2 test analysis of changes in the detection rate of hyperthyroidism. Results A total of 1995 cases of hyperthyroidism were found, the average annual case detection rate was 17.78 / 100000, of which, the detection rate was 14.55 / 100000 in 2000-2003, the detection rate in 2004-2009 was 19.85 / 100000, the latter stage was significantly higher than The former stage (χ2 = 42.83, P <0.01). Patients with an average thyroid volume of 46.15ml, enlargement rate of 79.80%, thyroid volume and swelling rate showed a downward trend (F = 22.13,62.84, P <0.01). Thyroid volume and goiter rate showed a decreasing trend with age (F = 31.02, 117.50, P <0.01 / 0.05). More women than men (1: 2.5) In the 20 to 50 age group (92.94%). Conclusion The detection rate of hyperthyroidism in Fuling District increased from 2000 to 2009. The thyroid volume and the rate of thyroid enlargement in hyperthyroid patients showed a decreasing trend, which may be related to iodine salt in the whole nation.