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经过10多年实验与临床方面的研究,单克隆抗体(Monoclonal antibody McAb)的放射免疫显像(Radioimmuno imaging RII)在大肠癌病人诊断中的应用取得了较大的进展。本文就单克隆抗体放射免疫显像在大肠癌病人中的应用现状以及存在的一些问题作一综述。 一、关于McAb Rll显像的原理 利用肿瘤组织内存在的抗原性物质,把针对肿瘤内某一抗原决定簇的核素标记的McAb经过一定途经(如静脉,腹腔)注入人体,标记McAb与针对的抗原发生结合,借助于体外显像,根据肿瘤组织内结合大量放射性同位素标记的McAb,把肿瘤组织与正常组织区别开来,发现肿瘤部位,数目,大小,为肿瘤病人的诊断及进一步的处理提供依据。 在放射免疫显像中,肿瘤组织对标记单抗的结合
After more than 10 years of experimental and clinical research, radioimmunoimmunoimaging (Radioimmuno imaging RII) of monoclonal antibodies (MCA) has made great progress in the diagnosis of colorectal cancer. In this paper, the application status of monoclonal antibody radioimmunoimaging in patients with colorectal cancer and some existing problems are reviewed. 1. Principles of McAb Rll Imaging The use of antigenic substances present in tumor tissue to inject a radiolabeled McAb that targets an antigenic determinant in a tumor into the body via a certain route (eg, vein, peritoneal cavity), marking McAb and targeting The antigens are combined and the in vitro imaging is used to distinguish the tumor tissue from the normal tissue based on a large number of radioactive isotope-labeled McAbs in the tumor tissue. The tumor site, number, and size are found to diagnose and further treat the tumor patient. Provide evidence. In radioimmunoimaging, the binding of tumor tissue to labeled monoclonal antibodies