论文部分内容阅读
源于二高-γ-亚麻油脂酸,由磷脂酶A_2活化限速的体内强大内源性扩血管物质前列腺素E_1（PGE_1）的扩血管作用和抑制血小板活性作用仅次于前列环素,并与前列环素存在部分共同受体,主要在肺内产生、肺内代谢。目前发现外源性PGE_1可抑制疾病状态下过度活化的血小板活性,如某些心血管疾病、肾脏疾病、糖尿病都伴有不同特点的血小板活性增加及血管内皮或肾系膜细胞的异常,并有内源性扩血管前列腺素生成减少或效应减低,因而补充外源性前列腺素E_1可能有益。
The vasodilator and inhibitory activity of platelet derived from prostaglandin E_1 (PGE_1), a potent and endogenous vasodilator activated by phospholipase A 2 and activated by phospholipase A 2, is second only to prostacyclin And prostacyclin exist some co-receptors, mainly in the lungs, lung metabolism. It has been found that exogenous PGE 1 can inhibit over-activated platelet activity in the disease state, such as certain cardiovascular diseases, kidney diseases, diabetes are associated with different characteristics of platelet activity and vascular endothelial or mesangial cell abnormalities, and Endogenous vasodilator prostaglandin production decreased or decreased effect, so supplementing exogenous prostaglandin E_1 may be beneficial.