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目的:进行前瞻性研究,寻找手足口病重症的成因及发病机理。方法:对2 143例手足口病患者的临床资料进行总结,并提出相关问题进行思考,试图从医学免疫学角度寻找答案,为今后的研究寻求一个突破口。结果:初步认为手足口病重症多由变态反应为主导的免疫性损伤引起,至少与以下三点有关:①手足口病病毒发生变异;②人体免疫功能紊乱,导致超敏反应;③人体抗原性变异。结论:总结手足口病重症的成因:①手足口病病毒发生变异;②人体免疫功能紊乱,导致超敏反应“有关;③人体抗原性变异。正因目前尚无足够证据充分论证,故提出”人体抗原性变异“假想。
Objective: To conduct a prospective study to find the causes and pathogenesis of HFMD. Methods: The clinical data of 2 143 cases of hand, foot and mouth disease were summarized and some related problems were put forward. The author tried to find out the answer from the perspective of medical immunology and find a breakthrough for future research. Results: It is preliminarily thought that HFMD is mostly caused by allergic reaction-induced immune injury, at least with the following three points: ① Mutation of hand-foot-and-mouth disease virus; ② Immune dysfunction of human body leading to hypersensitivity reaction; ③ Human antigenicity variation. Conclusion: The causes of severe hand-foot-mouth disease are summarized as follows: ① Variation of hand-foot-mouth disease virus; ② Human immune dysfunction leading to hypersensitivity reaction; ③ Human antigenic variation is precisely because there is not enough evidence to conclude that ”Human antigenic variation " hypothetical.