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目的研究缺氧诱导因子-1α(HIF-1α)在舌鳞癌组织、癌旁正常舌组织中表达状况及与舌癌进展之间的关系。方法采用半定量免疫印迹法(Western blot)检测40例舌鳞癌组织和癌旁正常舌组织中HIF-1α的表达。结果HIF-1α在舌癌组织中的表达水平明显高于癌旁正常组织中的表达水平(P<0.05)。HIF-1α表达与舌癌的临床TNM分期、淋巴结转移有关(P<0.05),与性别、年龄、组织学类型无关(P>0.05)。结论HIF-1α在舌癌的进展中具有重要作用,与疾病发展进程密切相关。
Objective To investigate the relationship between hypoxia inducible factor-1α (HIF-1α) expression in tongue squamous cell carcinoma and adjacent normal tongue tissues and its relationship with tongue cancer progression. Methods The expression of HIF-1α in 40 cases of tongue squamous cell carcinoma and adjacent normal tongue tissues was detected by semi-quantitative Western blotting. Results The expression of HIF-1α in tongue cancer tissues was significantly higher than that in adjacent normal tissues (P <0.05). The expression of HIF-1α was related to clinical TNM stage and lymph node metastasis (P <0.05), but not to sex, age and histological type (P> 0.05). Conclusion HIF-1α plays an important role in the progress of tongue cancer and is closely related to the development of the disease.