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目的:评价头孢唑啉与甲硝唑不同程疗对盆腔炎产妇剖宫术感染的预防效果及其安全性。方法:选取2014年2月—2016年2月间收治的盆腔炎产妇剖宫术感染患者90例,采用随机综合平衡法将产妇分为对照组(45例)和观察组(45例);对照组产妇给予头孢唑啉与甲硝唑联用长程(qd,连用5d)治疗,观察组产妇给予头孢唑啉与甲硝唑短程(q8h,用药3次,仅用药1 d)治疗,评价两组产妇用药后感染的发生率、产后新生儿Apger评分值和抗菌药物治疗费用。结果:两组产妇用药后子宫内膜炎症的发生率、产褥病的发生率、术后血象升高的发生率和用药期间不良反应的发生率经组间比较其差异均无统计学意义(P>0.05),产后新生儿的Apgar评分值和新生儿感染的发生率经组间比较其差异均无统计学意义(P>0.05);观察组产妇抗菌药物治疗费用低于对照组(P<0.05)。结论:盆腔炎产妇剖宫术感染采用头孢唑啉与甲硝唑短程(1 d)治疗与长程(5 d)治疗均具有相同的预防效果,短程治疗安全性高,降低了抗菌药物费用。
Objective: To evaluate the preventive effect and safety of different courses of cefazolin and metronidazole on cesarean section infection in pelvic inflammatory disease. Methods: Totally 90 pregnant women with pelvic inflammatory disease who were treated by pelvic inflammatory disease were selected from February 2014 to February 2016. The pregnant women were divided into control group (45 cases) and observation group (45 cases) by random integrated balance method. Group maternal cefazolin and metronidazole combined with long-term (qd, continuous use of 5d) treatment, the observation group of women given cefazolin and metronidazole short-course (q8h, medication 3, only 1 d treatment), evaluation of two groups Maternal drug infection rate, postpartum neonatal Apger score and antibacterial drug treatment costs. Results: The incidence of endometrial inflammation, the incidence of puerperal disease, the incidence of postoperative hemogram and the incidence of adverse reactions during the medication were not significantly different between the two groups (P> 0.05) P> 0.05). There was no significant difference between the two groups in the Apgar score and the incidence of neonatal infection (P> 0.05). The cost of antimicrobial treatment in the observation group was lower than that in the control group (P < 0.05). CONCLUSION: Cefazolin and metronidazole short-course (1 d) treatment has the same preventive effect in long-term (5 d) treatment of cesarean infection in cesarean section. Safety of short-range treatment is high, and the cost of antimicrobial drugs is reduced.