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为了指导临床合理使用抗菌药物,减少和控制耐药菌株的形成,我们连续10年采用横断面研究和前瞻性研究的方法对全院17095例病人(其中9432例住院病人和7663例门诊病人)逐一分科进行抗菌药物使用情况的分类统计和系统分析了耐药率变化,发现抗菌药物的应用与细菌的耐药性二者之间关系密切:抗菌药物的使用率与细菌的耐药率呈现非线性相关关系;当抗菌药物的耐药率大于一定比例时(如50%～70%左右),其使用率将迅速大幅度下降,这将意味着这一药物在5年以后将失去临床使用价值.
In order to guide the rational use of antimicrobial agents clinically and to reduce and control the formation of drug-resistant strains, we conducted cross-sectional studies and prospective studies for 10 years in a row for 17095 patients in our hospital (9432 inpatients and 7,663 outpatients) Disaggregated statistical analysis of the use of antimicrobial drugs and systematic analysis of changes in drug resistance and found that the use of antimicrobial drugs and bacterial resistance between the two closely related: the rate of antibacterial drugs and bacterial resistance showed a nonlinear When the rate of antimicrobial resistance is greater than a certain percentage (eg, about 50% -70%), the rate of rapid decline in its use rate will mean that the drug will lose clinical value after 5 years.