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本文对30例男性慢性肾功能衰竭(CRF)非透析患者性激素水平及14例男性血液透析(HD)患者HD前后性激素的变化进行观察,并与36例正常男性成年人性激素作对比分析。发现CRF患者血清催乳素(PRL)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_2)明显高于正常人(P<0.01),睾酮(T)明显低于正常人(P<0.01);HD患者HD后PRL、FSH、LH明显增高(P<0.01或0.05);而HD患者性激素和非HD患者比较无显著差异(P>0.05)。非HD患者T与血清肌酐(Scr)呈负相关,E:与Scr呈正相关。结合文献探讨了CRF患者性功能和内分泌变化的关系。
In this paper, the changes of sex hormones in 30 cases of non-dialysis patients with chronic renal failure (CRF) and the changes of sex hormones before and after HD in 14 cases of hemodialysis (HD) were observed and compared with those of 36 normal male adults. The serum level of prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) in CRF patients were significantly higher than those in normal subjects (P <0.01) (P <0.01). In HD patients, the levels of PRL, FSH and LH were significantly increased (P <0.01 or 0.05), while there was no significant difference between HD patients and non-HD patients (P> 0.05). Non-HD patients T and serum creatinine (Scr) was negatively correlated, E: and Scr was positively correlated. The relationship between sexual function and endocrine changes in patients with CRF was discussed in combination with the literature.