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目的探讨四川省绵阳市耐多药结核病耐药现状及特点,为制定耐多药结核病控制策略提供参考依据。方法收集全市10个结核病专业防治机构2012-2013年推送的500例耐药可疑肺结核患者药敏试验资料,采用Excel2003及SPSS17.0统计软件进行统计学分析。结果绵阳市耐多药肺结核病患者耐多药率为12.70%,广泛耐药率为0.60%;男女性别耐多药率差异无统计学意义;耐多药年龄分布高峰出现在35岁~年龄组(耐多药率18.18%);复治患者耐多药率(36.99%)高于初治患者(8.51%);送样地区城区耐多药率(22.22%)高于其他县市区;耐多药耐药谱有12种不同组合形式,以同时耐异烟肼、利福平和同时耐异烟肼、利福平、氧氟沙星2种组合为多。结论及早发现肺结核患者,早期、联合、适量、规律、全程规范治疗和管理新患者,结合健康促进工作防止耐药结核病产生是当前耐多药结核病防控工作的重点。
Objective To investigate the status and characteristics of multidrug-resistant tuberculosis (MDR-TB) in Mianyang City, Sichuan Province, and to provide a reference for the development of multi-drug resistant tuberculosis control strategies. Methods The drug susceptibility test data of 500 drug-resistant suspicious pulmonary tuberculosis patients from 10 TB professional prevention and treatment institutions in the city from 2012 to 2013 were collected and statistically analyzed by Excel2003 and SPSS17.0 statistical software. Results In MDR-TB patients, the MDR rate was 12.70% and the rate of extensive drug resistance was 0.60%. There was no significant difference in sex-MDR among men and women. The peak age of MDR-age appeared in 35-year-old age group (MDR 18.18%). The multidrug resistance rate (36.99%) in retreatment patients was higher than that in untreated patients (8.51%). The MDR rates in urban areas were higher than those in other counties (22.22%) Multidrug resistance spectrum has 12 different combinations, at the same time isoniazid, rifampicin and at the same time isoniazid, rifampin, ofloxacin two kinds of combination of more. Conclusion Early detection of tuberculosis patients with early, combined, appropriate, regular, full regulation and treatment of new patients, combined with health promotion work to prevent the emergence of drug-resistant TB is the focus of prevention and control of multidrug-resistant tuberculosis.