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应用生物素-链霉亲和素酶联免疫吸附测定法(BSA-ELISA)测定35名健康人3、5例T2DM患者及30例DMC患者血浆CT-1水平。结果 DMC显著高于T2DM组及正常组(P<0.001);T2DM高于正常组(P<0.05)。Pearson相关分析结果显示显示血浆CT-1水平与LAD(R=0.679,P<0.001);LVPW(R=0.537,P<0.001);CK-MB(R=0.309,P<0.01);IVS(R=0.191,P<0.05);TG(R=0.168,P<0.05)相关;多元逐步回归分析发现影响血浆CT-1水平的最显著因素为LAD、LVPW。结论糖尿病患者血浆CT-1水平升高表明已开始有心肌病变的进行;DMC患者CT-1升高更为明显,有助于DMC的早期诊断。
Plasma CT-1 levels were measured in 35 healthy subjects, 3,5 T2DM patients and 30 DMC patients by biotin-streptavidin-linked enzyme-linked immunosorbent assay (BSA-ELISA). Results DMC was significantly higher than T2DM group and normal group (P <0.001), T2DM higher than normal group (P <0.05). Pearson correlation analysis showed that plasma CT-1 levels were significantly correlated with LAD (R = 0.679, P <0.001), LVPW (R = 0.537, P <0.001) = 0.191, P <0.05), and TG (R = 0.168, P <0.05). The most significant factor influencing plasma CT-1 levels was found to be LAD and LVPW by multivariate stepwise regression analysis. Conclusion The increase of plasma CT-1 level in diabetic patients indicates that cardiac pathology has begun to take place. The increase of CT-1 in DMC patients is more obvious and contributes to the early diagnosis of DMC.