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目的分析尿激酶溶栓对脑梗死患者美国国立卫生研究院神经功能缺损(national institute of health stroke scale,NIHSS)评分和血液流变指标的影响。方法选取2014年6月—2015年6月的98例脑梗死患者,采用保护脑细胞、降低颅内压、改善微循环等常规治疗的有49例患者,在常规治疗基础上采用尿激酶溶栓治疗的有49例患者。比较治疗前后的神经功能和血液流变学变化,计量资料比较采用t检验,P<0.05为差异有统计学意义。结果对照组和观察组溶栓治疗前NIHSS评分分别为(23.25±3.18)、(23.47±2.56)分,治疗后分别为(15.36±2.02)、(9.74±1.59)分,治疗后两组评分均显著低于治疗前,且观察组显著低于对照组,对比差异均有统计学意义(均P<0.05)。两组患者治疗前的血流指数对比差异无统计学意义(P>0.05)。治疗后各项指标均显著低于治疗前,且观察组血液流变学水平较对照组低,对比差异均有统计学意义(均P<0.05)。结论血栓溶解治疗尿激酶可以改善脑血液循环和神经功能缺损,提高脑梗死患者的生活质量。
Objective To analyze the influence of urokinase thrombolysis on the score of national institute of health stroke scale (NIHSS) and hemorrheological index in patients with cerebral infarction. Methods A total of 98 patients with cerebral infarction from June 2014 to June 2015 were enrolled in this study. Forty-nine patients with conventional therapy of protecting brain cells, decreasing intracranial pressure and improving microcirculation were enrolled in this study. Urokinase thrombolysis Forty-nine patients were treated. Comparing the changes of neurological function and hemorheology before and after treatment, t test was used to compare the measurement data, P <0.05 was considered statistically significant. Results The NIHSS scores before and after thrombolysis in control group and observation group were (23.25 ± 3.18) and (23.47 ± 2.56), respectively, and were (15.36 ± 2.02) and (9.74 ± 1.59) after treatment respectively. Significantly lower than before treatment, and the observation group was significantly lower than the control group, the difference was statistically significant (P <0.05). There was no significant difference in blood flow index between the two groups before treatment (P> 0.05). After treatment, all indexes were significantly lower than before treatment, and the observation group, the level of blood rheology than the control group, the difference was statistically significant (P <0.05). Conclusion Thrombolytic therapy of urokinase can improve cerebral blood circulation and neurological deficits and improve the quality of life in patients with cerebral infarction.