醒脑注射液的急性毒性实验研究

• 作 者: 陈兰英 沈滟 陈玲 赵大治 赵志强 杨社道 赵会军 林滢 王宏敏
• 机 构: 洛阳市第二中医院
• 出 处: 洛阳医专学报
• 发表日期: 1997年01期
• 关键词: 急性毒性实验 醒脑注射液 大鼠 最大耐受量 组织损伤 药对 局部毒性反应 实验动物 清热化瘀 明显损伤

将醒脑注射液注射于大鼠体内后，对其最大耐受量、局部毒性反应以及不同剂量对大鼠一般反应及相关生理指标的影响进行实验研究。结果表明，该药对大鼠无毒副反应，未引起大鼠死亡。在用药后不同时间内对各剂量组的心率、呼吸、体温、进食、饮水等指标的测量和t检验结果，与对照组无显著差异，且四肢活动正常，局部无红肿等表现，病检结果也证明该药未引起组织损伤与坏死。

After injection of Xingnae injection into rats, the maximum tolerance, local toxicity and the effect of different doses on the rats’ general response and related physiological indexes were studied experimentally. The results showed that the drug had no toxic side effects on rats and did not cause death in rats. There were no significant differences in the measurement of heart rate, respiration, body temperature, eating, drinking and other indicators and t-test results between the dose groups at different times after administration. There were no significant differences between the doses and the control group, and normal limb movements, no local swelling, etc., and the results of the medical examination. It also proved that the drug did not cause tissue damage and necrosis.