论文部分内容阅读
目的:探讨体质量指数(BMI)与我国女性乳腺癌发病及临床病理特点的关系。方法:将413女性例乳腺癌患者(乳腺癌组)和同期425例接受普查的健康女性(对照组)的BMI值做总体分析与按年龄分层(<60岁和≥60岁)的比较,并将年龄、BMI与乳腺癌发病率的关系行Logistic回归分析,以及分析BMI与乳腺癌患者临床病理特征的关系。结果:总体上,乳腺癌组平均BMI明显高于对照组[(25.80±3.57)kg/m2vs.(25.28±3.19)kg/m2,P=0.029],按年龄分层后发现BMI差异仅存在于≥60岁组(Z=-3.408,P=0.001);Logistic回归分析显示BMI≥30 kg/m2发生乳腺癌风险明显增高(OR=1.892,95%CI=1.125～3.181,P=0.016),而年龄不影响乳腺癌的发病风险(P>0.05);BMI与乳腺癌腋窝淋巴结转移及HER-2/neu表达有关(均P<0.05),而与肿瘤大小、组织学分级、ER和PR状态无关(均P>0.05)。结论:BMI与我国的乳腺癌的发病有关,BMI测定可以帮助筛查乳腺癌高危人群,为主动预防、评估预后、实施有效治疗提供参考。
Objective: To explore the relationship between body mass index (BMI) and the incidence of breast cancer in women and clinicopathological features in China. Methods: The overall analysis of the BMI values of 413 women with breast cancer (breast cancer) and 425 healthy women undergoing censuses (control group) during the same period was compared with age stratified (<60 and ≥60) The relationship between age, BMI and incidence of breast cancer was analyzed by Logistic regression analysis, and the relationship between BMI and clinicopathological features was analyzed. Results: In general, the average BMI in breast cancer group was significantly higher than that in the control group [(25.80 ± 3.57) kg / m2 vs (25.28 ± 3.19) kg / m2, P = 0.029] Logistic regression analysis showed that the risk of breast cancer was significantly higher in patients with BMI≥30 kg / m2 (OR = 1.892, 95% CI = 1.125-3.181, P = 0.016), while those in ≥60 years old group (Z = -3.408, Age did not affect the risk of breast cancer (P> 0.05). BMI was correlated with axillary lymph node metastasis and HER-2 / neu expression in breast cancer (all P <0.05), but not with tumor size, histological grade, ER and PR status (All P> 0.05). Conclusion: BMI is related to the incidence of breast cancer in our country. BMI can help to screen the high risk population of breast cancer and provide a reference for active prevention, assessment of prognosis and effective treatment.