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目的 探索嗜酸性粒细胞趋化蛋白(eotaxin-3)基因+2497、+77位点单核苷酸多态性(SNP)与支气管哮喘(哮喘)易感性、类型的关系.方法 选择哮喘患者196例(哮喘组)、经体检健康者196例(对照组),其中哮喘组嗜酸细胞性哮喘(EA)140例、非嗜酸细胞性哮喘(NEA)56例.采用聚合酶链反应-限制性片段长度多态性技术检测eotaxin-3 SNP,ELISA法检测血浆eotaxin-3水平.结果 哮喘组eotaxin-3+2497位TG基因型频率、等位基因G的频率高于对照组(P均0.05).NEA患者+2497位TG型频率高于EA患者(PT,+2497T >G were detected by PCR-RFLP.ELISA was used to detect the level of eotaxin-3 in plasma.Results The geno-type frequency of eotaxin-3 +2497 TG and allele frequency of eotaxin-3 +2497G in the asthma group were significantly higher than those of the control group (all P 0.562).The frequency of eotaxin-3 +2497 TG genotype in NEA patients was significantly higher than that in EA patients (P <0.05).The level of eotaxin-3 in TG genotype asthmatic patients was significantly lower than that in TT genotype (P G is associated,but eotaxin-3 +77 is not associated with asthma susceptibility,eosinophilic asthma and non-eosinophilic asthma.