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目的研究2型糖尿病初始治疗患者服用糖尿病1号中药验方对炎症因子的临床作用。方法选择2014—2015年的2型糖尿病初期或者初始治疗患者48例,随机分为中药组和西药组,每组24例。西药组采用赖脯胰岛素注射液(25R)联合二甲双胍片和阿卡波糖片进行治疗;中药组采用糖尿病1号中药验方进行治疗。记录并比较治疗前后2组患者体质量指数(BMI)、空腹血糖、白介素6、肿瘤坏死因子α、白介素1β的结果变化。结果与治疗前比较,西药组和中药组均能有效降低患者的空腹血糖(P<0.05);中药组能明显降低白介素6、肿瘤坏死因子α、白介素1β(P<0.05),而西药组不能降低炎症因子;同时2组患者的BMI也无明显变化。中药组的不良反应发生率小于对照组(P<0.05)。结论糖尿病1号中药验方能降低糖尿病患者血糖和抑制炎症因子;同时低血糖和胃肠道等不良反应发生率相对低,依从性好。该验方适用于炎症因子引起的糖尿病,抗炎机制可能是其治疗糖尿病的作用机制之一。
Objective To study the clinical effect of Diabetes No.1 Prescription on inflammatory factors in patients with initial treatment of type 2 diabetes. Methods Forty-eight patients with initial or initial type 2 diabetes mellitus (2014-2015) were randomly divided into two groups: traditional Chinese medicine group and western medicine group, with 24 cases in each group. The western medicine group was treated with insulin lispro injection (25R) combined with metformin tablets and acarbose tablets. The traditional Chinese medicine group was treated with Diabetes No.1 prescription medicine. The changes of body mass index (BMI), fasting blood glucose, interleukin 6, tumor necrosis factor α and interleukin 1β in two groups before and after treatment were recorded and compared. Results Compared with those before treatment, the Western medicine group and the traditional Chinese medicine group were able to effectively reduce the fasting blood glucose (P <0.05), while the Chinese medicine group could significantly reduce interleukin 6, tumor necrosis factor α and interleukin 1β (P <0.05) Reduce inflammatory cytokines; while the two groups of patients with no significant change in BMI. The incidence of adverse reactions in the TCM group was less than that in the control group (P <0.05). Conclusions Diabetes No.1 prescription can reduce the blood sugar and inhibit the inflammatory factors in diabetic patients. Meanwhile, the incidence of adverse reactions such as hypoglycemia and gastrointestinal tract is relatively low and the compliance is good. The prescription for the inflammation caused by diabetes, anti-inflammatory mechanism may be one of its mechanisms of treatment of diabetes mellitus.