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分析了20株中国人肿瘤细胞的O~6-甲基鸟嘌呤DNA甲基转移酶(O~6-MT)活性及对嘧啶亚硝脲ACNU的敏感性,发现两者间有较好的线性关系,O~6-MT低,对ACNU敏感,提示O~6-MT可作为使用ACNU对肿瘤化疗时的一项予见性指标。
The activity of O~6-methylguanine DNA methyltransferase (O~6-MT) in 20 Chinese tumor cells and the sensitivity to pyrimidine nitrosoureas ACNU were analyzed. It was found that there was a good linearity between the two. The relationship, low O~6-MT, is sensitive to ACNU, suggesting that O~6-MT can be used as a predictive indicator for the use of ACNU in cancer chemotherapy.