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目的观察来氟米特与柳氮磺吡啶分别联合甲氨蝶呤治疗强直性脊柱炎对患者血清白介素-33(IL-33)、瘦素水平的影响。方法将304例强直性脊柱炎患者随机分为A组(102例)、B组(102例)、C组(100例)。其中A组采用来氟米特联合甲氨蝶呤治疗,B组采用柳氮磺吡啶联合甲氨蝶呤治疗,C组采用单纯甲氨蝶呤治疗,比较3组患者治疗前后血清IL-33、瘦素水平。结果治疗后3组患者血清IL-33、瘦素均较治疗前明显下降(P<0.05),且治疗后A、B组血清IL-33、瘦素水平均低于C组(P<0.05),而A、B组血清IL-33、瘦素水平差异均无统计学意义(P>0.05)。结论来氟米特与柳氮磺吡啶分别联合甲氨蝶呤治疗强直性脊柱炎的疗效均优于单纯甲氨蝶呤,且联合治疗的2组疗效未见显著性差异。
Objective To observe the effects of leflunomide combined with sulfasalazine and methotrexate on serum levels of interleukin-33 (IL-33) and leptin in patients with ankylosing spondylitis. Methods 304 patients with ankylosing spondylitis were randomly divided into group A (102 cases), group B (102 cases) and group C (100 cases). Among them, group A was treated with leflunomide and methotrexate, group B was treated with sulfasalazine and methotrexate, group C was treated with methotrexate alone, and serum IL-33, Leptin level. Results Serum levels of IL-33 and leptin in three groups after treatment were significantly lower than those before treatment (P <0.05), and the levels of IL-33 and leptin in A and B groups were lower than those in C group after treatment (P <0.05) , While the levels of serum IL-33 and leptin in group A and group B had no significant difference (P> 0.05). Conclusion The efficacy of leflunomide combined with sulfasalazine and methotrexate in the treatment of ankylosing spondylitis is better than that of methotrexate alone. There is no significant difference between the two groups in the combination therapy of leflunomide and sulfasalazine.