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目的评价60°C碘油栓塞对兔VX2肝癌的抑瘤效果。方法将VX2瘤细胞接种于30只新西兰白兔肝左叶,建立兔肝癌模型,随机分3组,每组10只。经导管向肝动脉分别注入生理盐水、37°C碘油、60°C碘油,1周后观察各组肿瘤体积及血清AST水平,以及瘤兔的存活期。结果60°C碘油组生长率(0.92±0.21)与对照组(3.48±1.17)、37°C碘油组(1.29±0.26)相比有差异(P<0.05)。60°C碘油组存活期(41.0±3.0)与对照组(31.5±3.0)相比有差异(P<0.05)。60°C碘油组血清AST水平与37°C碘油组相比无差异(P>0.05),与对照组相比有差异(P<0.05)。结论60°C碘油组可降低肿瘤生长率,延长存活期,肝功的损害是可逆的,且抑瘤效果更强。
Objective To evaluate the antitumor effect of 60 ° C lipiodol embolization on VX2 liver cancer in rabbits. Methods VX2 tumor cells were inoculated into the left lobe of the liver of 30 New Zealand white rabbits to establish a model of rabbit liver cancer and were randomly divided into 3 groups with 10 in each group. Into the hepatic artery via the catheter were injected normal saline, 37 ° C iodized oil, 60 ° C lipiodol, 1 week after the observation of tumor volume and serum AST levels, as well as the survival of tumor rabbits. Results The growth rate of 60 ° C lipiodol group (0.92 ± 0.21) was significantly lower than that of control group (3.48 ± 1.17) and 37 ° C lipiodol group (1.29 ± 0.26) (P <0.05). 60 ° C lipiodol group survival (41.0 ± 3.0) compared with the control group (31.5 ± 3.0) difference (P <0.05). The level of serum AST in 60 ° C lipiodol group was not significantly different from that in 37 ° C lipiodol group (P> 0.05), which was significantly different from that in control group (P <0.05). Conclusion 60 ° C lipiodol group can reduce the tumor growth rate, prolong survival, liver damage is reversible, and the anti-tumor effect is stronger.