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目的观察早期康复治疗加用依达拉奉治疗急性脑梗死(ACI)的疗效。方法采用随机对照试验,选择发病48h内的ACI患者68例,随机分为依达拉奉治疗组(34例)及对照组(34例),治疗前后定期对患者进行神经功能缺损评定,日常生活活动能力(ADL)评定,神经功能缺损评定采用美国国立卫生院卒中量表(NIHSS),ADL评定采用Barthel指数量表,以治疗第21天NIHSS和ADL改变作为主要疗效判断标准。应用SPSS10.0软件进行统计学处理。结果21d后治疗组、对照组NIHSS相比差异有显著性(P<0.05);两组ADL相比差异有显著性(P<0.01),治疗组无明显不良反应。结论早期康复治疗基础上加用依达拉奉是一种改善急性脑梗死患者神经功能缺失的有效治疗方案,值得进一步评价。
Objective To observe the curative effect of early rehabilitation therapy and edaravone on acute cerebral infarction (ACI). Methods A randomized controlled trial was conducted. Sixty-eight patients with ACI within 48 hours of onset were randomly divided into edaravone treatment group (n = 34) and control group (n = 34). The patients were evaluated on neurological deficits and daily activities before and after treatment Assessment of activity (ADL), neurological deficit assessment using the National Institutes of Health Stroke Scale (NIHSS), ADL assessment Barthel index scale, to treat the NIHSS and ADL changes on the 21st day as the main efficacy criteria. Application SPSS10.0 software for statistical analysis. Results 21d after treatment, the control group NIHSS difference was significant (P <0.05); ADL between the two groups was significantly different (P <0.01), no significant adverse reactions in the treatment group. Conclusion The early rehabilitation treatment based on the use of edaravone is an effective treatment for patients with acute cerebral infarction to reduce neurological deficits, it is worth further evaluation.