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目的:了解乙型和丙型肝炎病毒感染与原发性肝细胞癌(HCC)的病因学关系.方法:病例对照研究,以39例肝硬化伴发HCC为测试组,48例肝硬化为对照组,利用免疫组织化学染色观察肝组织切片中乙型(HBsAg/HBcAg)和丙型(HCVAg)肝炎病毒抗原的阳性率.结果:HBsAg/HBcAg阳性率在HCC组(23/39,58.97%)和肝硬化组(24/48,50%)之间无显著统计学差异.HBV和HCV抗原同时阳性者在HCC组(14/39,35.89%)高于肝硬化组(9/48,18.7%),但其差别亦达不到统计学显著性.然而,HCC组HCVAg阳性率(19/39,48.72%)显著高于肝硬化组(9/48,18.75%)P<0.001;HCVAg阳性时发生HCC的机会比为4.11(95%可情区间为1.58至10.74).结论:尽管HBV感染仍是HCC的主要病因,HCV感染对于HCC的发生亦起重要作用.
Objective: To understand the etiological relationship between hepatitis B and C viral infections and primary hepatocellular carcinoma (HCC). Methods: Case-control study of 39 cases of liver cirrhosis with HCC as the test group and 48 cases of liver cirrhosis as controls Group, using immunohistochemical staining to observe the positive rate of hepatitis B virus antigen (HBsAg/HBcAg) and hepatitis C (HCVAg) in liver tissue sections. Results: The positive rate of HBsAg/HBcAg in HCC group (23/39, 58.97%) There was no significant difference between the cirrhosis group and the cirrhosis group (24/48, 50%). The positive HBV and HCV antigens were higher in the HCC group (14/39, 35.89%) than in the cirrhotic group (9/48, 18.7%). However, the difference was not statistically significant. However, the positive rate of HCVAg in the HCC group (19/39, 48.72%) was significantly higher than that in the cirrhotic group (9/48, 18.75%) P<0.001; when HCVAg was positive The odds ratio for HCC was 4.11 (95% range 1.58 to 10.74). Conclusion: Although HBV infection is still the main cause of HCC, HCV infection also plays an important role in the occurrence of HCC.