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3批酵母源性乙型肝炎疫苗半纯化2批,纯化1批,按不同剂量分为5μg、10μg和20μg3组。另外,1批半纯化疫苗增加1组40μg,纯化疫苗增加1组2.5μg。2批血源性乙型肝炎疫苗均为20μg。将778名抗-HBs阴性者随机分成13组,按第0、1和2个月程序进行初免后,第12个月各组均用20μg酵母疫苗再作1次加强免疫。结果表明,酵母疫苗是安全的,反应轻微,与血源疫苗无明显区别。接种第3剂酵母疫苗后1个月,抗体未阳转者占全部受种者的0～7%,加强免疫后1个月,则全部阳转。两种不同类型的疫苗诱生的阳转率无显著差别。接种第3剂血源疫苗后,抗-HBs几
Three batches of yeast-derived hepatitis B vaccine were semi-purified two batches, purified one batch, divided into 5μg, 10μg and 20μg3 groups according to different doses. In addition, one batch of semi-purified vaccine increased by 40 μg in group 1 and the purified vaccine increased by 2.5 μg in group 1. Two batches of blood-borne hepatitis B vaccine were 20μg. A total of 778 anti-HBs-negative patients were randomly divided into 13 groups. After the first immunization with 0, 1 and 2 months, the 12th month of each group was boosted with 20μg of yeast vaccine. The results show that the yeast vaccine is safe, mild reaction, no significant difference with the blood-borne vaccine. One month after inoculation of the third dose of yeast vaccine, the antibody did not turn positive accounted for 0 ~ 7% of all the recipients, one month after boosting, then all positive. There was no significant difference in the positive rate of infection induced by the two different types of vaccines. After inoculation of the third dose of the blood source vaccine, several anti-HBs