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作者研究了1958-1959年在莫斯科4个地区243个曾有包特金氏病发生的托儿所和幼儿园的接触者5,862人。对部分接触者应用丙种球蛋白0.15毫升/公斤体重,以预防包特金氏病,结果如下:应用血清预防后,在20-25％的儿童机构中没有发生流行,仅60％接触者中有病例发现。但在不同的流行条件下所得到的效果是不同的,在第一次发现病例后即进行接种者,其发病率可减少5.8倍,而在再次发现病例后接种者,效果难于肯定,除去在接种第16天后发生的病例外,其发病率可减少2倍。
The authors studied 5,862 contacts from 243 nurseries and kindergartens where there was a history of package-like disease in 1958-1959 in four districts of Moscow. Application of gamma globulin 0.15 ml / kg body weight to some contacts for the prevention of Baggett’s disease resulted in the following: No sequelae occurred in 20-25% of children’s institutions after seroconversion, with only 60% of contacts having Case finding. However, the effects obtained under different prevailing conditions are different. The incidence of vaccination after the first discovery is 5.8 times less. However, the effect of vaccination after finding the disease is difficult to be confirmed. In addition to the cases occurring after 16 days of vaccination, the incidence can be reduced by a factor of two.