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脂蛋白脂酶为脂质代谢的重要酶 ,在体内分布脏器不同 ,表现出不同的作用特点。脂蛋白脂酶在血浆中具有水解甘油三酯作用 ,对防治动脉粥样硬化病变有利。在动脉壁内 ,细胞基质中的脂蛋白脂酶有滞留蛋白作用 ;巨噬细胞膜上的脂蛋白脂酶能促进低密度脂蛋白和极低密度脂蛋白进入该细胞内 ,使巨噬细胞转变为泡沫细胞 ;脂蛋白脂酶还能刺激血管壁平滑肌细胞增生等 ,脂蛋白脂酶表现出致动脉粥样硬化作用。本文还综述了多种体内外因素对脂蛋白脂酶代谢与活性的影响。
Lipoprotein lipase is an important enzyme in lipid metabolism, distribution of organs in the body different, showing different roles. Lipoprotein lipase in the plasma with triglyceride hydrolysis, prevention and treatment of atherosclerotic lesions beneficial. Within the arterial wall, the lipoprotein lipase in the cell matrix has a retention protein effect; lipoprotein lipase on the macrophage membrane can promote the entry of low density lipoproteins and very low density lipoproteins into the cells, transforming the macrophages into Foam cells; lipoprotein lipase can stimulate vascular smooth muscle cell proliferation, lipoprotein lipase showed atherogenic role. This article also reviewed the effects of various in vitro and in vivo factors on lipoprotein lipase metabolism and activity.