毒蕈碱受体M3的表达与呼吸道疾病

• 作 者: 王羽 戴路明
• 机 构: 昆明医学院第一附属医院呼吸二科,
• 出 处: 医学综述
• 发表日期: 2012年01期
• 关键词: 毒蕈碱受体 呼吸道疾病 呼吸道 M3 肿瘤坏死因子α 白细胞介素 干扰素γ 炎性因子 受体 乙酰胆碱

M3受体广泛分布于呼吸道平滑肌中,通过与乙酰胆碱结合而引起呼吸道收缩,腺体分泌和呼吸道重构。近年研究表明,哮喘和慢性阻塞性肺疾病炎性反应中产生的各种炎性因子,如白细胞介素1β、白细胞介素13、肿瘤坏死因子α和干扰素γ等能影响M3受体在呼吸道内的表达,使M3受体表达上调。因此,使用长效选择性胆碱能受体拮抗剂能延缓肺功能下降,在慢性阻塞性肺疾病的治疗中有重要作用。

M3 receptors are widely distributed in airway smooth muscle and cause respiratory constriction, glandular secretion and airway remodeling by binding to acetylcholine. In recent years, studies have shown that various inflammatory factors such as interleukin 1β, interleukin 13, tumor necrosis factor α and interferon γ in the inflammatory reaction of asthma and chronic obstructive pulmonary disease can affect the expression of M3 receptor in the respiratory tract The expression of M3 receptors is up-regulated. Therefore, the use of long-acting selective cholinergic receptor antagonists can delay the decline in lung function and play an important role in the treatment of chronic obstructive pulmonary disease.