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新药Encainide属Ⅰ类抗心律失常药。目前,国外主要用于治疗室性心律失常,对各种室性早搏都能接近完全抑制,对某些持久性室性心动过速和室颤也有一定疗效,且所用剂量较小,毒性作用较少。为了更好地了解Encainide的作用特点,现对其电生理学作用、临床药理学和抗心律失常效应综述如下。 一、电生理学作用 Encainide对离体和在体心肌的电生理学作用,国外学者已进行了大量的研究。Gibson等在离体犬浦氏纤维上研究了Encainide的电生理作用,发现10~(-6)M
Encainide is a class I antiarrhythmic drug. At present, foreign mainly for the treatment of ventricular arrhythmias, a variety of ventricular premature beats can be close to complete inhibition of some of the persistent ventricular tachycardia and ventricular fibrillation have a certain effect, and the use of smaller doses, less toxic effects . In order to better understand the role of Encainide features, now its electrophysiological effects, clinical pharmacology and anti-arrhythmic effects are summarized below. First, the electrophysiological role of Encainide on isolated and in vivo myocardial electrophysiology, foreign scholars have conducted a large number of studies. Gibson et al investigated the electrophysiological effects of Encainide on isolated Canine fibers and found that 10 ~ (-6) M