论文部分内容阅读
[目的]评价局部晚期非小细胞肺癌(NSCLC)接受放化疗综合治疗结果。[方法]46例局部晚期非小细胞肺癌接受图像引导放疗联合TP方案化疗模式治疗。化疗方法:国产多西紫杉醇(商品名希存,深圳万乐医药公司生产)75/m2静滴d 1,PDD(顺铂)25 mg/m2,静滴d 1～3。21～28 d为1个治疗周期。图像引导放疗方法:应用医科达Synergy医用直线加速器行图像引导放疗,中位放疗剂量62 Gy(55~69 Gy)。[结果]46例病人完全缓解4例,部分缓解33例,稳定6例,进展3例,总有效率81.4%(37/46)。1年生存率为71.7%(33/46)。放射性食管炎25例(54.3%),其中Ⅰ~Ⅱ级21例(45.6%),Ⅲ级4例(8.7%);放射性肺炎5例(10.9%),均为Ⅰ~Ⅱ级,经积极处理患者均可耐受。[结论]图像引导放疗联合TP方案化疗,疗效确切,副反应可以耐受,值得临床推广。
[Objective] To evaluate the results of combined chemotherapy and radiotherapy for locally advanced non-small cell lung cancer (NSCLC). [Method] 46 cases of locally advanced non-small cell lung cancer underwent guided radiotherapy combined with TP regimen chemotherapy. Chemotherapy: domestic docetaxel (brand name Xi deposit, Shenzhen Wan Le Pharmaceutical Company) 75 / m2 intravenous d 1, PDD (cisplatin) 25 mg / m2, intravenous drip d1 ~ 3.21 ~ 28 d 1 treatment cycle. Image-guided radiotherapy: Image-guided radiotherapy was performed using a Synergy Medical Linear Accelerator with a median dose of 62 Gy (55-69 Gy). [Result] Among the 46 patients, complete remission was achieved in 4 cases, partial remission in 33 cases, stabilization in 6 cases and progression in 3 cases. The total effective rate was 81.4% (37/46). The 1-year survival rate was 71.7% (33/46). There were 25 cases (54.3%) of esophagitis, 21 cases (45.6%) were grade Ⅰ ~ Ⅱ, 4 cases (8.7%) were grade Ⅲ, and 5 cases (10.9%) were grade Ⅰ ~ Ⅱ. Patients can be tolerated. [Conclusion] The radiofrequency imaging combined with TP regimen chemotherapy is effective and the side effects can be tolerated. It is worthy of clinical promotion.