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应激是机体对内外环境变化做出的总体反应,过度应激导致机体的组织坏死和器官衰竭,从而诱发应激损伤。细胞程序性坏死是一种新鉴定的可调控的程序性细胞死亡,具有明确的调控靶点和信号转导通路,且在缺血再灌注、外源微生物感染和炎症反应等应激因素诱导的组织损伤过程中具有重要的调控作用。同时,细胞程序性坏死抑制剂在多种应激损伤动物模型中都表现出显著的预防和治疗效果,从而表明阻断细胞程序性坏死将成为应激损伤预防和治疗的新策略,而细胞程序性坏死的调控靶蛋白也为应激损伤的药物设计提供了新的靶点。
Stress is the body’s overall response to changes in the internal and external environment, excessive stress causes the body’s tissue necrosis and organ failure, thus inducing stress damage. Cytopathic necrosis is a newly identified and regulated programmed cell death with clear regulatory targets and signal transduction pathways. It is also induced by stress factors such as ischemia-reperfusion, exogenous microbial infection and inflammatory reaction Tissue damage has an important regulatory role. At the same time, cytopathic necrosis inhibitors have shown significant preventive and therapeutic effects in various animal models of stress injury, suggesting that blockade of programmed cell death will be a new strategy for the prevention and treatment of stress injury, whereas the cellular program The target protein for the regulation of necrosis also provides a new target for the drug design of stress injury.