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本文比较了胎儿胸腺细胞、正常成人外周血Ｔ细胞及儿童扁桃体Ｔ细胞对丝裂原ＰＷＭ、ＰＨＡ和ＣｏｎＡ、ＰＫＣ激活剂ＰＭＡ和Ｃａ２＋导入剂Ａ２３１８７的反应性。结果表明：胎儿胸腺细胞对ＰＷＭ的反应对ＰＨＡ和ＣｏｎＡ的反应性很弱；正常成人外周血Ｔ细胞对ＰＨＡ的反应性最强，对ＰＷＭ和ＣｏｎＡ的反应性较弱；儿童扁桃体Ｔ细胞对３种丝裂原的反应性均很强；ＰＭＡ单独作用能强烈诱导儿童扁桃体Ｔ细对正常成人外周血Ｔ细胞及胸腺细胞作用较弱；ＰＷＭ和ＰＭＡ对胎儿胸腺细胞及正常成人外周血Ｔ细胞均有明显协同作用，但对儿童扁桃体Ｔ细胞无协同作用；Ａ２３１８７单独作用对３种Ｔ细胞的增殖作用均很弱，Ａ２３１８７对ＰＷＭ诱导的增殖均有部分抑制作用。这些结果对于认识处于不同发育阶段及不同部位的的活化途径和功能有一定意义。
This article compared the reactivity of fetal thymocytes, normal adult peripheral blood T cells, and pediatric tonsil T cells with mitogen PWM, PHA and ConA, PKC activator PMA and Ca2 + -introducing agent A23187. The results showed that the responses of fetal thymocytes to PWM were weakly responsive to PHA and ConA. The normal adult peripheral blood T cells had the strongest reactivity to PHA and the weak reactivity to PWM and ConA. The reactivity of all kinds of mitogen was very strong. The effect of PMA alone on the T-cells and thymocytes in normal adult children was strongly induced by T-allergen. Tumor cells of both thymocytes and normal adult human T cells A23187 had a synergistic effect but no synergistic effect on children’s tonsil T cells. A23187 alone had a weak proliferation effect on all three T cells, and A23187 partially inhibited the proliferation induced by PWM. These results have some significance for understanding the activation pathways and functions at different developmental stages and different sites.