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目的 :本文观察了 70例进展期胃癌手术前后血清睾酮的变化。方法 :采用放射性免疫化学方法测定进展期胃癌和对照组手术前后血清睾酮的变化。结果 :52例男性胃癌患者手术前血清睾酮( 32 63± 5 62 )nmol/L , x±s)与良性疾病对照组 ( 4 2 92± 8 93)nmol/L相比明显降低 (P <0 0 1) ;手术后 3个月复查血清睾酮 ( 4 0 84± 6 53)nmol/L比术前升高 (P <0 0 1) ;与良性疾病对照组入院时已无明显差别 (P >0 0 5) ;术后复发组血清睾酮 ( 2 8 66± 8 74 )nmol/L与术后 3个月时相比再次下降 (P <0 0 1)。女性胃癌患者术后血清睾酮 ( 2 32± 0 4 7)nmol/L比术前 ( 1 73± 0 34 )nmol/L也明显升高 (P<0 0 1)。结论 :结果提示血清睾酮可以做为胃癌诊断、治疗和观察复发的一个辅助指标
Objective: This study was to observe the changes of serum testosterone in 70 patients with advanced gastric cancer before and after surgery. Methods: The changes of serum testosterone in advanced gastric cancer and control group before and after operation were measured by radioimmunochemistry. Results: Serum testosterone (32 63 ± 522 nmol / L, x ± s) in 52 cases of gastric cancer patients before operation was significantly lower than that of benign disease control group (4292 ± 893 nmol / L) (4 0 84 ± 6 53 nmol / L) were significantly higher than those preoperatively (P 0 01). There was no significant difference between the two groups (P> 0.05). Serum testosterone (2 8 66 ± 8 74) nmol / L in recurrent group decreased again compared with 3 months after operation (P 0 01). Serum testosterone (2 32 ± 0 47) nmol / L in postoperative women with gastric cancer was significantly higher than that preoperatively (1 73 ± 0 34) nmol / L (P 0 01). Conclusion: The results suggest that serum testosterone can be used as a secondary indicator of gastric cancer diagnosis, treatment and observation of recurrence