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临床上氯丙嗪引起粒细胞减少并非少见,但引起溶血性贫血较少见。 1 病例介绍 患者女,42岁,因头昏、乏力、纳差2a,加重半年入院。既往有“精神分裂症”病史16a,长期眼用氯丙嗪,无药物过敏史,家族中无遗传性疾病,无溶血性贫血亲属。查体:贫血貌,巩膜黄染,双肺未闻及干湿性罗音,心率120次/min,律齐,心界向左扩大,腹软,肝右胁下8cm,剑下5cm,质硬,脾左助下平脐,质硬,腹水征(-),双下肢凹陷性水肿。入院后血常规:RBC2.1×10~(12)/L,WBC2.O×l0~9/L,血小板P_2×10~9/L。周围血细胞形态:可见中幼及晚幼红细胞,血
Chlorpromazine clinically cause neutropenia is not uncommon, but cause hemolytic anemia is less common. A case description Female patient, 42 years old, due to dizziness, fatigue, anorexia 2a, increased six months admission. Previously had a history of “schizophrenia” 16a, long-term ophthalmic chlorpromazine, no history of drug allergy, no genetic disease in the family, no hemolytic anemia relatives. Physical examination: anemia, scleral yellow dye, lungs unheard of smell and wet and dry rales, heart rate 120 beats / min, law Qi, heart to the left to expand, abdominal soft, right under the threat of liver 8cm, Hard, spleen left under the flat navel, hard, signs of ascites (-), double lower limb depression edema. After admission, blood routine: RBC 2.1 × 10 ~ (12) /L, WBC2.O × 10 ~ 9 / L, platelets P 2 × 10 ~ 9 / L. Peripheral blood cell morphology: young and late visible red blood cells, blood