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目的通过对糖调节受损(IGR)和新诊断2型糖尿病(NDD)患者氧化应激水平的检测探讨氧化应激与2型糖尿病(T2D)的关系。方法纳入78名IGR患者,113名NDD患者和92名血糖正常(NGT)对照,进行问卷调查、体格检测和基本的生化、抗氧化指标检测。结果与NGT对照相比,IGR患者红细胞过氧化物歧化酶(SOD)活性降低。NDD患者血浆丙二醛(MDA)水平较NGT对照升高,但血浆总抗氧化能力(TAC)和红细胞SOD活性降低。关联性分析显示胰岛素抵抗与血浆MDA浓度有较强的正相关性,但与血浆TAC水平和红细胞SOD活性负相关。对于β细胞功能,与血浆TAC水平显著正相关,而与红细胞谷胱甘肽(GSH)浓度负相关。结论 IGR状态的高血糖导致的氧化应激可能促进β细胞功能受损,胰岛素抵抗和更明显的高血糖。
Objective To investigate the relationship between oxidative stress and type 2 diabetes (T2D) by detecting oxidative stress in patients with impaired glucose regulation (IGR) and newly diagnosed type 2 diabetes (NDD). Methods A total of 78 IGR patients, 113 NDD patients and 92 normal controls were included in this study. Questionnaires, physical examinations and basic biochemical and antioxidant indexes were performed. Results Compared with NGT control, the activity of erythrocyte superoxide dismutase (SOD) in IGR patients was decreased. Plasma malondialdehyde (MDA) levels in NDD patients were higher than those in NGT controls, but plasma total antioxidant capacity (TAC) and erythrocyte SOD activity were decreased. Correlation analysis showed a strong positive correlation between insulin resistance and plasma MDA concentration, but negatively correlated with plasma TAC level and erythrocyte SOD activity. There was a significant positive correlation between beta-cell function and plasma TAC levels, but negative correlation with erythrocyte glutathione (GSH) concentrations. Conclusions Oxidative stress induced by hyperglycemia in IGR status may promote impaired beta-cell function, insulin resistance and more pronounced hyperglycemia.