Effect of Homoharringtonine on Corneal Haze after Excimer Laser Photorefractive Keratectomy in Rabbi

• 作 者: ZHANG Mingchang WANG Li WANG Yong DING Zhengping MAI Caikeng NIE Shaosong CHEN Fei
• 机 构: Department of Ophthalmology, Union Hospital, Tongji Medical College of Huazhong University of Scienc
• 出 处: 华中科技大学学报（医学英德文版）
• 发表日期: 2005年6期
• 关键词: Homoharringtonine PRK Haze

To evaluate the inhibiting effect of Homoharringtonine HHT) on the ceal haze after excimer laser photorefractive keratectomy (PRK) in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into three groups (A, B and C). The refractive degree of ablation was -10. 0DS in each group. Group A was locally treated with a piece of filter paper soaked with 1 mg/mi HHT for 5 min, and then the entire cea was repeatedly irrigated with balance solution;Group B was dropped with 0.1 mg/mL HHT after PRK for 3 months; Group C was the control group. Ceal haze, histopathology, response, ect. were investigated. The ceal haze was sig nificantly less in group A, while the difference between group B and group C was insignificant.Keratocytes and fibrocytes in ceal stroma were more active up to 3 months in group B and group C. Intraoperative use of topical HHT can reduce ceal haze after PRK in rabbits.