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过去很少重视MDS病人BM(骨髓)活检的价值。本研究的目的是对126例根据FAB标准诊断为MDS病人的BM活检作形态学特点分析。通过应用单变量和多变量方法学,探讨组织病理发现的价值,使有关形态学数据和可能影响生存的因素达到一致。94％的数据提示以上两者间是一致的。 72例(57％)男性,54例(43％)女性,中数年龄66岁(31—87岁),5例(4％)为40岁以下。126例病人的中数生存期是15.5个月(95％置信限分别11.2和21.4)。63％的病例骨髓细胞成分是增加的,特别是在难治性贫血伴原始细胞增多(RAEB)、难治性贫血伴原始细胞增多转变型(RAEB-t)和慢性粒单细胞性白血病(CMML)的病例(P=0.001)。
In the past, the value of BM (bone marrow) biopsy in MDS patients was seldom emphasized. The purpose of this study was to analyze morphological features of BM biopsies of 126 patients diagnosed with MDS based on FAB criteria. By applying univariate and multivariate methodologies, the value of histopathologic findings is explored to bring the relevant morphological data into line with factors that may affect survival. 94% of the data suggest that the two are consistent. 72 (57%) males and 54 (43%) females, the median age of 66 years (31-87 years) and 5 patients (4%) under 40 years of age. The median survival for 126 patients was 15.5 months (95% confidence interval, 11.2 and 21.4, respectively). Bone marrow cell components are increased in 63% of cases, especially in refractory anemia with increased blasts (RAEB), refractory anemia with blasts (RAEB-t), and chronic myelomonocytic leukemia ) Cases (P = 0.001).