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小鼠腹腔注射3.7×10~2—3.7×10~5Bq/gbw HTO(氚水)作为适应剂量,随后全身照射1.5Gy~(60)Coγ射线作为激发剂量,观察对骨髓细胞染色单体畸变率的影响。结果表明:以3.7×10~3Bq/gbwHTO组诱发的适应性反应最明显,当高达3.7×10~5Bq/gbw时适应性反应似乎消失;在腹腔注射3.7×10~3Bq/gbw后,1—5d内照射激发剂量1.5Gy均可观察到适应性反应,以第5d最显著,观察值相当于预期值的50％,至第7d时观察值接近于预期值;照射激发剂量后随着时间的延长染色单体畸变率逐渐降低,如果以适应性反应指数表示,激发剂量照射后24h达最大值0.52。
Mice were intraperitoneally injected with 3.7×10 2 -3.7×10 5 Bq/gbw HTO as an adaptive dose, and then irradiated with 1.5 Gy 60 γ Co γ-rays as an excitation dose to observe the rate of chromatid monomer aberration in bone marrow cells. Impact. The results showed that the adaptive response induced by 3.7×10~3Bq/gbw HTO group was the most obvious. The adaptive response seemed to disappear when the frequency was as high as 3.7×10~5Bq/gbw. After intraperitoneal injection of 3.7×10~3Bq/gbw,1— The adaptive response could be observed after 5d internal irradiation excitation dose 1.5Gy, which was the most significant on the 5th day. The observation value was equivalent to 50% of the expected value. The observed value was close to the expected value on the 7th day; The prolonged chromatid aberration rate gradually decreased. If the adaptive response index was expressed, the maximum dose was 0.52 at 24 hours after the excitation dose.