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Objective: The aim of this study was to investigate the clinical, radiographic and histiopathologic features of multicentric giant cell tumor of bone. Methods: All the clinical data of twenty tumors in nine patients of multicentric giant cell tumor that underwent surgical treatment in our department from 1990 to 2010 were retrospectively reviewed, which included three males and six females. The patients ranged from 15 to 45 years at diagnosis, with an average age of 22.3 years. Three of the patients were younger than twenty years of age. Most tumors arose in long bones, especially around the knee. Radiographically, the tumors in long bones usually manifested as expansive lytic lesions involving the metaphysis and extending into the epiphysis. Three tumors in three patients were confined to the metaphysis, and one tumor exhibited bone-forming lesions. All tumors were treated with curettage or resection. Results: The typical "giant cell" could be found in the oncologic examination in all cases. In some areas, such as the fibrohistiocytic regions, reactive bone forming and aneurysmal bone cyst-like changes could be found. Follow-up averaged 3.5 years, ranging from 6 months to 12 years. There was a recurrence of three tumors, and one patient died of pulmonary metastasis. Conclusion: Multicentric giant cell tumor occur often in younger patients than do solitary giant cell tumor. They are frequently present around the knee, and confined to the metaphysis. Each tumor arose independently, rather than being in multiple sites of metastatic lesion that develop from a single tumor. The risk of recurrence depends on the type of surgery that is performed.