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第1、2鳃弓是胚胎发育过程中的重要结构,可分化为颅面骨骼、耳等结构。鳃弓发育异常可导致斑马鱼、大鼠等动物产生颅面、耳等结构畸形。Forkhead(Fox)蛋白家族是胚胎发育过程中的关键转录因子,该家族中Foxi在胚胎内外胚层的不同时期有相应程度的表达,foxi1基因突变斑马鱼存在颚骨、耳板缺失及鳃弓神经嵴细胞凋亡增加等异常,Foxi1突变大鼠、狗等动物中也有相似异常。Foxi蛋白可能通过先驱因子作用调节早期胚胎发育过程中相关基因的表达,影响整个胚胎颅面结构的形成。
The first and second gill arch is an important structure in the process of embryonic development, which can differentiate into craniofacial skeleton, ear and other structures. Branchial dysfunction can cause zebrafish, rats and other animals produce craniofacial, ear and other structural deformities. The Forkhead (Fox) protein family is a key transcription factor during embryonic development. In this family, Foxi is expressed in different stages of embryonic endoderm and ectoderm, and foxi1 mutant zebrafish has jaw bone, missing ear plate, Apoptosis and other abnormalities, Foxi1 mutant rats, dogs and other animals also have similar abnormalities. Foxi protein may regulate the expression of related genes in the process of early embryogenesis through the function of a pioneer factor and affect the formation of the craniofacial structure of the entire embryo.