脑内吗啡肽类(脑内鸦片制剂)及其临床上的应用

• 作 者: 梁德年
• 机 构: 黑龙江中医学院生化教研室,
• 出 处: 中医药学报
• 发表日期: 1980年Z1期
• 关键词: 吗啡 鸦片制剂 神经药理学 脑啡肽 吗啡制剂 鸦片 多肽类 化学结构 镇痛作用 作用机理

一、脑啡肽(Enkephalin)及内啡肽(Endorphin) 在神经药理学领域内,最近20年间,最大的收获之一就是有关吗啡的作用部位及其作用机理的研究进展,特别是吗啡类受体的发现并予以证实,同时也相继发现了:脑内吗啡样因子(Morphine Like factor·MLF)的化学结构,尤其是脑啡肽与内啡肽的发现。从广义而言之,可将脑内吗啡样因子称为吗啡制剂(鸦片制剂)Opiates:又称为吗啡(鸦片)样物质(Opiods)。其中含有多肽类的,特称为吗啡(鸦片)多肽类(Opiod peptides)。

1. Enkephalin and Endorphin In the field of neuropharmacology, one of the biggest gains in the last 20 years has been the research progress on the site of action of morphine and its mechanism of action, especially morphine The discovery of the body and confirmation, but also found one after another: the chemical structure of the brain morphine-like factor (Morphine Like factor · MLF), especially the discovery of enkephalin and endorphin. In a broad sense, brain morphine-like factors may be referred to as morphine preparations (opiates) Opiates: also known as opiates (Opiods)-like substances (Opiods). Among them, polypeptides are known as opiate (Opiod peptides).