Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271

• 作 者: Weiyu Shen Yumei Li Bifei Li L
• 机 构: CancerMetastasisAlertandPreventionCenter,DepartmentofPharmacy,InstituteofOceanography
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2019年3期
• 关键词: KCTD12 MITF CD271 MELANOMA CANCER metastasis CANCER stem cell
• 基金项目: supported by grants from the Ministry of Science and Technology of China(Grant No.2015CB931804),National Natural Science Foundation of China(Grant No.U1505225,81773063,81273548,81571802),the Natural S

Objective: Cancer metastasis remains the primary cause of cancer-related death worldwide.In a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma cells.The purpo