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目的:探讨甲胎蛋白(AFP)含量与慢加急性肝衰竭预后的关系,进一步了解肝衰竭患者AFP含量的变化。方法:将回顾分析的65例慢加急性肝衰竭患者根据最后治疗结果分为存活组与死亡组,分析对比两组在不同时间AFP含量的差异,同时观察AFP含量与总胆红素(TBil),凝血酶原活动度(PTA)的关系。结果:65例患者中AFP含量高于正常者53例(81.54%),存活组不同时期的AFP含量平均值均高于死亡组,有显著差别(P<0.01)。AFP含量升高(≥300 IU/mL)主要分布在血清总胆红素<510μmoL/mL,凝血酶原活动度>30%患者中,随AFP含量升高,病死率下降。结论:慢加急性肝衰竭患者血清AFP含量升高反应了肝细胞再生活跃,提示预后良好。
Objective: To investigate the relationship between the content of AFP and the prognosis of patients with acute liver failure, and further understand the changes of AFP in patients with liver failure. Methods: A retrospective analysis of 65 patients with acute and chronic liver failure patients were divided into survivors and deaths according to the results of the final treatment. The differences of AFP levels between the two groups were analyzed and compared. The levels of AFP and total bilirubin (TBil) , Prothrombin activity (PTA) relationship. Results: The AFP content in 65 patients was higher than that in 53 patients (81.54%). The average AFP content in surviving group was higher than that in death group (P <0.01). AFP levels increased (≥ 300 IU / mL) mainly in serum total bilirubin <510μmoL / mL, prothrombin activity> 30% of patients, with increasing AFP content, mortality decreased. CONCLUSIONS: Increased serum AFP levels in patients with acute and chronic liver failure respond to the active regeneration of hepatocytes, suggesting a good prognosis.