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抗细胞毒相关基因A(CagA)产物的粘膜IgA抗体和循环中IgG抗体的存在与活动期十二指肠溃疡和重度胃炎密切相关。近有报道称抗CagA IgG抗体在与慢性胃炎有关的胃癌患者中增高,因此有必要了解其存在是否与胃癌的癌前病变——胃粘膜萎缩有关。 方法:患者年龄18～70岁,均经内镜检查并在胃窦部和胃体部分别取6块和3块活检标本。胃窦部标本中的2块作Hp培养,1块作尿
The presence of mucosal IgA antibodies and circulating IgG antibodies against the cytotoxic-related gene A (CagA) product is closely related to active duodenal ulcer and severe gastritis. It has recently been reported that anti-CagA IgG antibodies are elevated in patients with gastric cancer associated with chronic gastritis and it is therefore necessary to know whether their presence is associated with a precancerous lesion of gastric cancer, gastric mucosal atrophy. Methods: The patients were aged from 18 to 70 years old. All of them were examined by endoscopy and 6 and 3 biopsy specimens were taken from the antrum and the corpus. Two specimens from the antrum were cultured for Hp and one for urine