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目的：探讨慢性肾功能衰竭（ＣＲＦ）患者血清三碘甲状腺原氨酸（Ｔ３）、甲状腺素（Ｔ４）和促甲状腺激素（ＴＳＨ）水平的变化及其临床意义。方法：采用放射免疫分析法测定６６例ＣＲＦ患者血清Ｔ３、Ｔ４和ＴＳＨ的含量，并与３０例正常人作对照分析。结果：ＣＲＦ患者失代偿期血清Ｔ３、Ｔ４水平随血尿素氮（ＢＵＮ）、肌酐（Ｃｒ）的升高而渐降低，与对照组比较均有显著性差异（Ｐ均＜０．０５）；ＴＳＨ与血ＢＵＮ和Ｃｒ的升高无关，治疗后Ｔ３、Ｔ４水平随病情好转而渐升高（Ｐ均＜０．０５）。结论：血清Ｔ３、Ｔ４水平可作为判断ＣＲＦ病情、观察药物疗效和预后的指标。
Objective: To investigate the changes of serum triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) in patients with chronic renal failure (CRF) and its clinical significance. Methods: The serum levels of T3, T4 and TSH in 66 patients with CRF were determined by radioimmunoassay and compared with 30 normal controls. Results: Serum levels of T3 and T4 in decompensated CRF patients gradually decreased with the increase of blood urea nitrogen (BUN) and creatinine (Cr), which were significantly different from those in control group (all P <0.05). TSH was not related to the increase of blood BUN and Cr. After treatment, the levels of T3 and T4 gradually increased with the improvement of the disease (all P <0.05). Conclusion: Serum T3 and T4 levels can be used as indicators of CRF severity and efficacy and prognosis.