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邻氯青霉素(Cloxacillin)和氟氯西林(flucloxacillin)属异恶唑类青霉素.广泛用于对青霉素耐药性金黄色葡萄球菌感染的治疗.氟氯西林具有口服吸收良好,体内消除缓慢的特点.所以,血药浓度比邻氯青霉素要高.作者在健康自愿受试者身上进行了两药的生物利用度比较.选择9名健康自愿受试者,年龄20～24岁,男7例,女2例.给药前10小时,给药后2小时内禁食,给药后4小时用标准餐.所有受试者口服邻氯青霉素胶囊500mg后,
Cloxacillin and flucloxacillin are isoxazoles, penicillins, are widely used in the treatment of penicillin-resistant Staphylococcus aureus, and are well orally absorbed and slowly eliminated in the body. Therefore, the blood concentration is higher than that of cloxacillin.The authors compared the bioavailability of two drugs in healthy volunteers, and selected nine healthy volunteers aged 20-24 years, 7 males and 2 females Example 10 hours before administration, fasting within 2 hours after administration, standard meal 4 hours after administration.All subjects were treated with 500 mg of o -chlorophenol capsule,