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内毒素系指革兰氏阴性细菌细胞壁中的脂多糖(LPS)成分,结构上有三部分组成,即“O”抗原、核心及类脂A。类脂A为其活性中心。内毒素对机体有广泛的作用,少量进入机体可引起发热、白细胞减少(后增多)、血液成分如补体、激肽、凝血、纤溶等系统功能的改变;大量进入可引起重要脏器(如心、肺、肝、肾、眼等)发生器质性损害及功能衰竭,严重者可发生内毒素休克甚至死亡。近年来的研究认为,内毒素在金黄色葡萄球菌引起的中毒性休克综合征(TSS)的发生中亦起重要作用,因而引起了许多基础医学工作者及临床医生的重视。本文就内毒素在TSS的发生、发展中所起的作用及其作用
Endotoxin is the component of lipopolysaccharide (LPS) in the cell wall of Gram-negative bacteria. It is structurally composed of three components, namely the antigen, core and lipid A. Lipid A is its active center. Endotoxin has a wide range of effects on the body, a small amount into the body can cause fever, leukopenia (later increased), blood components such as complement, kinin, coagulation, fibrinolysis and other system changes; a large number of access to important organs Heart, lung, liver, kidney, eye, etc.) occurred in the organic damage and failure, severe endotoxic shock may occur and even death. Recent studies suggest that endotoxin also plays an important role in the pathogenesis of Staphylococcus aureus-induced toxic shock syndrome (TSS), which has attracted the attention of many basic medical workers and clinicians. This article on the role of endotoxin in the occurrence and development of TSS and its role