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鬼臼毒素(1)是一种临床上用于抗肿瘤等的木脂素类化合物。鬼臼毒素类的抗肿瘤作用机制已知有两种:一种为抑制微管蛋白的聚合作用和阻断中期相细胞分裂,另一种为抑制 DNA 拓扑异构酶活性。鬼臼毒素7位差向异构体的醚或糖甙类衍生物多是通过
Podophyllotoxin (1) is a lignan compound that is clinically used for antitumor and the like. There are two known anti-tumor mechanisms of podophyllotoxins: one is inhibition of tubulin polymerization and blocking of metaphase cell division, and the other is inhibition of DNA topoisomerase activity. Most of the ether or glycoside derivatives of the 7-epimer podophyllotoxin are