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为评价新洁尔灭（Ｇ１２）对真菌性角膜病的治疗效果，用注射法复制真菌性角膜病动物模型，并采用０．００５％Ｇ１２，对实验性真菌性角膜病进行治疗。结果表明，４０只家兔８０只眼全部出现典型的真菌性角膜病。治疗后角膜溃疡愈合情况差异显著；前房积脓，两周内差异不显著，两周后差异显著；角膜穿孔及角巩膜葡萄肿差异不显著。结论：注射法复制真菌性角膜病动物模型优于滴入法和划痕法；Ｇ１２具有减轻症状和体征并缩短病程的作用；Ｇ１２有可能成为临床治疗真菌性角膜病理想的眼局部用药。
To evaluate the efficacy of benzalkonium bromide (G12) in the treatment of fungal keratopathy, an animal model of fungal keratopathy was reproduced by injection and treated with experimental fungal keratopathy using 0.005% G12. The results showed that 80 eyes of 40 rabbits showed typical fungal keratopathy. Corneal ulcer healing was significantly different after treatment; empyema in the anterior chamber, the difference was not significant within two weeks, two weeks after the difference was significant; corneal perforation and corneal scleral swelling was not significantly different. Conclusion: The animal model of fungal keratopathy by injection is superior to the method of dropping and scratching. G12 can relieve symptoms and signs and shorten the course of the disease. G12 may be an ideal ophthalmic topical treatment for fungal keratopathy.