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目的分析多发性骨髓瘤(MM)的临床特征,提高对该病的认识及整体疗效。方法回顾性分析51例MM患者的临床资料、治疗方法、疗效及治疗不良反应。结果 51例MM患者中,骨痛、乏力、感染是常见症状。47例有不同程度的贫血,肾功能损害35例,均出现血β2-MG增高,IgG型最常见,Ⅲ期患者46例。治疗以VAD、M2、MP等方案化疗为主。加用沙利度胺和IFN-α,疗效优于单用化疗。结论 MM临床表现多样化,瘤细胞的免疫表型检查值得在临床工作中推广。化疗联用沙利度胺和IFN-α,可改善患者生存质量,延长生存时间。
Objective To analyze the clinical features of multiple myeloma (MM) and to improve the understanding of the disease and its overall efficacy. Methods Retrospective analysis of 51 cases of MM patients with clinical data, treatment methods, efficacy and treatment of adverse reactions. Results 51 cases of MM patients, bone pain, fatigue, infection is a common symptom. 47 cases had different degrees of anemia and 35 cases of renal dysfunction. Both of them showed elevated blood β2-MG, the most common IgG type and 46 cases of stage Ⅲ. Treatment with VAD, M2, MP and other chemotherapy programs based. Plus thalidomide and IFN-α, the effect is better than chemotherapy alone. Conclusion The clinical manifestations of MM are diversified. Immunophenotypic examination of tumor cells deserves promotion in clinical practice. Chemotherapy combined thalidomide and IFN-α, can improve the quality of life of patients and prolong survival time.