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目的 探讨病毒性心肌炎 (VM )患儿血清肌钙蛋白I(cTnI)水平及其临床意义。方法 采用ELISA法测定 6 6例VM患儿入院及治疗前后血清cTnI浓度。观察血清cTnI与心电图及心功能的关系 ,以及治疗前后超声心动图预后指标变化。结果 儿童VM血清cTnI显著升高 ,其升高幅度与心电图异常和心功能损害程度一致 ;VM治疗前后cTnI峰值下降幅度 (dcTnI) >5 0 % ,超声心动图显示预后判断指标优于dcTnI<5 0 % (P均 <0 .0 1)。结论 血清cTnI可作为儿童VM早期诊断及预后评价的指标之一
Objective To investigate the serum level of troponin I (cTnI) in children with viral myocarditis and its clinical significance. Methods Serum cTnI levels of 66 children with VM were measured by ELISA before and after admission. The relationship between serum cTnI and electrocardiogram (ECG) and cardiac function was observed, and the prognostic indicators of echocardiography before and after treatment were observed. Results The level of cTnI in children with VM was significantly higher than that in patients with abnormal ECG and heart function impairment. The peak value of cTnI decline was 50% before and after VM treatment. The echocardiography showed that the index of prognosis was better than dcTnI 0% (P <0.01). Conclusion Serum cTnI can be used as an indicator of early diagnosis and prognosis of children with VM