Karacoline,identified by network pharmacology, reduces degradation of the extracellular matrix in in

• 作 者: Xiaoli Zhou Yingying Hong Yuli
• 机 构: DepartmentofTraditionalChineseMedicine,DepartmentofBiology,OrthopedicsDepartment
• 出 处: 药物分析学报:英文版
• 发表日期: 2020年1期
• 关键词: Karacoline Network pharmacology INTERVERTEBRAL disc DEGENERATION EXTRACELLULAR M
• 基金项目: This work was supported by the Pudong New Area Science and Technology Committee of Shanghai(Grant No.PKJ2015-Y08).

Karacoline is a compound found in the plant Aconitum kusnezoffii Reichb.Although Aconitum kusnezoffii Reichb is widely used for the treatment of pain,very few studies have been carried out on the use of karacoline due to its potential toxicity.In this stu