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目的探讨尖吻蝮蛇血凝酶联合奥美拉唑治疗非静脉曲张性上消化道出血的临床效果及安全性。方法将90例非静脉曲张性上消化道出血患者随机分为治疗组和对照组各45例。二组均予补液、输血、营养支持等治疗。对照组使用奥美拉唑40mg q8h静滴。治疗组在此基础上加用尖吻蝮蛇血凝酶2ku q12h静推。观察止血效果及不良反应。结果治疗组总有效率为91.1%明显高于对照组73.3%,差异有统计学意义(P<0.05);治疗组止血时间、输血量、再出血例数均优于对照组,差异有统计学意义(P<0.05);2组不良反应例数无统计学差异(P>0.05)。结论尖吻蝮蛇血凝酶联合奥美拉唑能够有效治疗非静脉曲张性上消化道出血。
Objective To investigate the clinical efficacy and safety of Copepoda snake venom coagulase combined with omeprazole in the treatment of non-variceal upper gastrointestinal bleeding. Methods 90 patients with non-variceal upper gastrointestinal bleeding were randomly divided into treatment group and control group, 45 cases each. The two groups were rehydration, blood transfusion, nutritional support and other treatment. Control group omeprazole 40mg q8h intravenous infusion. On the basis of the treatment group, the treatment group was treated with 2ku q12h static massage. Hemostasis observed and adverse reactions. Results The total effective rate in the treatment group was 91.1%, which was significantly higher than that in the control group (73.3%), the difference was statistically significant (P <0.05). The bleeding time, blood transfusion and rebleeding in the treatment group were better than those in the control group (P <0.05). There was no significant difference in the number of adverse reactions between the two groups (P> 0.05). Conclusions Agkistrodon acutus combined with omeprazole can effectively treat non-variceal upper gastrointestinal bleeding.